abstract：PURPOSE:To evaluate the corneal button of primary penetrating keratoplasty of patients diagnosed with congenital aniridia. The study took place at the Instituto Universitario Barraquer and the Centro de Oftalmología Barraquer. METHODS:A retrospective analysis of cases diagnosed with congenital aniridia was carried out...

journal_title：Ophthalmic research

authors： Bausili MM,Alvarez de Toledo J,Barraquer RI,Michael R,Tresserra F,de la Paz MF

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To evaluate a technique of autologous internal limiting membrane (ILM) fragment transplantation for the treatment of large, chronic, and/or refractory macular holes (MH). DESIGN:This was a 6-month prospective interventional case series. METHOD:Ten eyes of 10 patients with MH underwent pars plana vitretomy (...

journal_title：Ophthalmic research

authors： De Novelli FJ,Preti RC,Ribeiro Monteiro ML,Pelayes DE,Junqueira Nóbrega M,Takahashi WY

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:To assess the cytotoxic properties of voriconazole and sulfobutylether-β-cyclodextrin (SBECD) on cultured primary human corneal epithelial cells. METHODS:Human corneal epithelial cells were cultured and exposed to various concentrations of SBECD (0.016-32 mg/ml) and voriconazole (0.001-2 mg/ml). Cellular cy...

journal_title：Ophthalmic research

authors： Sobolewska B,Guerel G,Hofmann J,Tarek B,Bartz-Schmidt KU,Yoeruek E

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Retinitis pigmentosa (RP) is an inherited retinal disorder, characterized by photoreceptor degeneration inducing progressive vision loss. This study evaluates its impact on quality of life (QOL) and emotional states of patients affected by RP. METHODS:A cross-sectional study was conducted on 60 RP patient...

journal_title：Ophthalmic research

authors： Azoulay L,Chaumet-Riffaud P,Jaron S,Roux C,Sancho S,Berdugo N,Audo I,Sahel JA,Mohand-Saïd S

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Retinal gene therapy trials are currently ongoing in a small number of inherited retinal disorders and this number is expected to rise significantly. The aim of this study was to analyze the psychological aspects of patients with RPE65 deficiency awaiting potential enrollment in gene therapy trials. METHODS:Fi...

journal_title：Ophthalmic research

authors： Nelles M,Stieger K,Preising MN,Kruse J,Lorenz B

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Abnormalities in electroretinograms (ERG), such as reduced amplitudes and delayed implicit times of a- and b-wave and oscillatory potentials (OPs), are one of the earliest features of diabetic retinopathy prior to obvious vascular changes in diabetic retinas. We have previously shown that serum levels of advanc...

journal_title：Ophthalmic research

authors： Maeda S,Matsui T,Ojima A,Suematsu M,Kaseda K,Higashimoto Y,Yamakawa R,Yamagishi S

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:It has been suggested that eye makeup could interact with human meibum causing a decrease in the stability of the tear film. The aim of this pilot study was to measure makeup-human meibum interactions in vitro. METHODS:Human meibum-makeup interactions were quantified by measuring order-to-disorder lipi...

journal_title：Ophthalmic research

authors： Hunter M,Bhola R,Yappert MC,Borchman D,Gerlach D

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes. METHODS:Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy St...

journal_title：Ophthalmic research

authors： Tejerina AN,Vujosevic S,Varano M,Egan C,Sivaprasad S,Menon G,Massin P,Verbraak FD,Lund-Andersen H,Martinez JP,Jurgens I,Smets E,Coriat C,Wiedemann P,Ágoas V,Querques G,Holz FG,Nunes S,Alves D,Neves C,Santos T,Ri

更新日期：2015-01-01 00:00:00

abstract：AIMS:To investigate whether allogeneic limbal mesenchymal stem cell (LMSC) therapy affects corneal healing after a severe chemical burn and whether the route of administration of LMSCs differs in its therapeutic effect in this respect. METHODS:A total of 60 Sprague-Dawley rats with clinically proven alkali injury were...

journal_title：Ophthalmic research

authors： Acar U,Pinarli FA,Acar DE,Beyazyildiz E,Sobaci G,Ozgermen BB,Sonmez AA,Delibasi T

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the effects of quercetin on vascular endothelial growth factor (VEGF)-induced choroidal and retinal angiogenesis in vitro using a rhesus macaque choroid-retinal endothelial (RF/6A) cell line. METHODS:RF/6A cells were cultured in Dulbecco's modified Eagle's medium contai...

journal_title：Ophthalmic research

authors： Li F,Bai Y,Zhao M,Huang L,Li S,Li X,Chen Y

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:To investigate the possible roles of various cytokines or growth factors in the pathogenesis of exudative age-related macular degeneration (AMD) by comparing aqueous humor levels of 14 cytokines between eyes with polypoidal choroidal vasculopathy (PCV) and those with neovascular AMD. METHODS:Forty eyes from 40...

journal_title：Ophthalmic research

authors： Sakurada Y,Nakamura Y,Yoneyama S,Mabuchi F,Gotoh T,Tateno Y,Sugiyama A,Kubota T,Iijima H

更新日期：2015-01-01 00:00:00

abstract：:Toxoplasma gondii is an extremely successful opportunistic parasite which infects approximately one third of the human population worldwide. The impact of this parasite on human health becomes particularly manifest in congenital damage with infection and subsequent inflammation of neuronal tissues including the retina...

journal_title：Ophthalmic research

authors： Pleyer U,Schlüter D,Mänz M

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To investigate the effects, and their reversibility, of multiple oral voriconazole doses on a variety of visual tests in healthy male volunteers. METHODS:Single-center, double-blind, randomized, placebo-controlled, parallel-group study in 36 volunteers who received voriconazole (n=18, 400 mg every 12 h on day ...

journal_title：Ophthalmic research

authors： Zrenner E,Tomaszewski K,Hamlin J,Layton G,Wood N

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To investigate whether different crush durations or a different fluorogold (FG) injection timing can affect the efficiency of FG retrograde labeling of retinal ganglion cells (RGCs) in the optic nerve (ON) crush model. METHODS:We performed the ON crush in rats with a clip at different durations or a jewel forc...

journal_title：Ophthalmic research

authors： Huang TL,Huang SP,Chang CH,Lin KH,Sheu MM,Tsai RK

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To investigate the antiangiogenic effect of itraconazole for the prevention of experimentally induced corneal neovascularization and whether the efficacy depends on the route of administration. MATERIALS AND METHODS:Thirty-six rats were randomly divided into 6 groups with 6 rats in each group. Chemical cauteri...

journal_title：Ophthalmic research

authors： Goktas S,Sakarya R,Erdogan E,Sakarya Y,Ozcimen M,Dursunoglu D,Kocacan M,Alpfidan I,Erdogan E,Bukus A,Ivacık IS

更新日期：2014-01-01 00:00:00

abstract：:Diabetic macular edema is considered the most important factor related to visual impairment in patients with diabetic retinopathy. Together with the use of grid and focal laser photocoagulation, today the intravitreal administration of pharmacotherapies represents the standard of care for the treatment of this complic...

journal_title：Ophthalmic research

authors： Bandello F,Preziosa C,Querques G,Lattanzio R

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To investigate therapeutic ocular surface medium (TOSM), a potential physiological tear replacement therapy, for persistent epithelial defect (PED). METHODS:11 eyes of 10 patients with PED for ≥ 2 weeks without improvement despite conventional treatment were enrolled in a prospective pilot study of TOSM over 1...

journal_title：Ophthalmic research

authors： Watson SL,Geerling G,Dart JK

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:By the release of antiangiogenic factors, Müller glial cells provide an angiostatic environment in the normal and ischemic retina. We determined whether Müller cells produce thrombospondin-1 (TSP-1), a known inhibitor of angiogenesis. METHODS:Secretion of TSP-1 by cultured Müller cells was determined w...

journal_title：Ophthalmic research

authors： Yafai Y,Eichler W,Iandiev I,Unterlauft JD,Jochmann C,Wiedemann P,Bringmann A

更新日期：2014-01-01 00:00:00

abstract：AIMS:To evaluate the biologic effects of fluoroquinolone eye solutions without preservatives on cultured human corneal epithelial cells in vitro. METHODS:We studied the effect of diverse generations of topical fluoroquinolones such as ofloxacin 0.3%, levofloxacin 0.5%, tosufloxacin 0.3%, moxifloxacin 0.5% and gatiflox...

journal_title：Ophthalmic research

authors： Oum BS,Kim NM,Lee JS,Park YM

更新日期：2014-01-01 00:00:00

abstract：AIM:Ultraviolet (UV) B irradiation induces gene expression that leads to skin cancer. Among the transcription factors induced by UVB radiation exposure, the cyclic AMP response element-binding protein (CREB) is significant. Since several factors downstream of CREB signaling are known to be involved in pterygium pathoge...

journal_title：Ophthalmic research

authors： Nubile M,Curcio C,Lanzini M,Calienno R,Iezzi M,Mastropasqua A,Di Nicola M,Mastropasqua L

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:The possibility of providing cultured corneal endothelial cells (CECs) for clinical transplantation has gained much attention. However, the worldwide need for human (h) donor corneas far exceeds supply. The pig (p) might provide an alternative source. The aim of this study was to compare the proliferative capac...

journal_title：Ophthalmic research

authors： Fujita M,Mehra R,Lee SE,Roh DS,Long C,Funderburgh JL,Ayares DL,Cooper DK,Hara H

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND/AIM:Corneal epithelial defects may heal slowly in patients with diabetes, limbal stem cell deficiency, extensive chemical burns or anesthetized corneas. Studies have shown that erythropoietin, a glycoprotein hormone that promotes red blood cell proliferation and inhibits apoptosis of erythroid progenitors, m...

journal_title：Ophthalmic research

authors： Livny E,Livnat T,Yakimov M,Masoud M,Weinberger D,Bahar I

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To compare the effects between intravitreal and periocular injections of adenoviral vectored pigment epithelium-derived factor (AdPEDF) on suppressing established choroidal neovascularization (CNV) in rats. METHODS:Sixty-eight female BN rats (136 eyes) aged 6-8 weeks were involved in this study. The CNV animal...

journal_title：Ophthalmic research

authors： Yan H,Cui J,Wang Y,Yu Y

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To compare tear film osmolarity (TFO) between patients with diabetes mellitus (DM) and normal healthy individuals. METHODS:In this prospective case-controlled study, the TFO in 46 normal subjects (control group) and 55 patients with DM (study group) was evaluated. TFO in milliosmole (mOsm) was measured by usin...

journal_title：Ophthalmic research

authors： Sağdık HM,Ugurbas SH,Can M,Tetikoğlu M,Ugurbas E,Uğurbaş SC,Alpay A,Uçar F

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility of a new technique for the implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium (RPE) cells into the subretinal space of retina-degenerate Royal College of Surgeon (RCS) rats. METHODS:A platform device was used for the implantation of 4-µm-t...

journal_title：Ophthalmic research

authors： Hu Y,Liu L,Lu B,Zhu D,Ribeiro R,Diniz B,Thomas PB,Ahuja AK,Hinton DR,Tai YC,Hikita ST,Johnson LV,Clegg DO,Thomas BB,Humayun MS

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To describe the characteristics of macular lesions after eye trauma using spectral-domain optical coherence tomography (OCT). METHODS:We retrospectively reviewed and described 2-dimensional (2D) and 3-dimensional (3D) spectral-domain OCT characteristics of 24 consecutive eyes of 24 cases that were identified w...

journal_title：Ophthalmic research

authors： Yu W,Zheng L,Zhang Z,Dai R,Dong F

更新日期：2012-01-01 00:00:00

abstract：AIMS:Mutations in the PAX6 are the major cause of congenital aniridia. The objective of this study was to analyze genetic mutations in PAX6 in Chinese patients with congenital aniridia. METHODS:Total genomic DNA was isolated from the peripheral blood of the aniridia patients, all healthy family members and 100 healthy...

journal_title：Ophthalmic research

authors： Luo F,Zhou L,Ma X,He Y,Zou L,Jie Y,Liu J,Pan Z

更新日期：2012-01-01 00:00:00

abstract：AIM/BACKGROUND:A 1-bp deletion (1147delA) in the SAG (also known as arrestin or S-antigen) gene is the most frequently seen mutation in Japanese patients suffering from Oguchi disease, a recessively inherited stationary night blindness. We investigated macular function in a patient with Oguchi disease with the 1147delA...

journal_title：Ophthalmic research

authors： Hayashi T,Tsuzuranuki S,Kozaki K,Urashima M,Tsuneoka H

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:To propose a new noncontact tonometer based on corneal photoelasticity. METHOD:In this study, we experimented with 18 enucleated porcine eyes. The anterior chamber was infused with a physiological solution. A circular polarizing filter was attached to an ophthalmic surgical microscope. Color fringe changes at ...

journal_title：Ophthalmic research

authors： Hwang H,Kim M,Park C

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To assess changes of tear film function in patients with pterygium after pterygium excision combined with limbal-conjunctival autograft transplantation. METHODS:Sixty eyes of 60 patients were entered in the study. The Schirmer test, tear breakup time (BUT) and mucus fern test (MFT) were evaluated in the pati...

journal_title：Ophthalmic research

authors： Wang S,Jiang B,Gu Y

更新日期：2011-01-01 00:00:00

abstract：:Oxidative stress plays a role in the pathogenesis of neurodegeneration in diabetic retinopathy (DR). However, whether an excellent reactive oxygen species scavenger, U83836E, inhibits the neurodegeneration in DR remains uncertain. This study is aimed at clarifying the effects of U83836E on DR. Two weeks after streptoz...

journal_title：Ophthalmic research

authors： Wang H,Zheng Z,Gong Y,Zhu B,Xu X

更新日期：2011-01-01 00:00:00

abstract：AIMS:Biomaterials are widely used in ophthalmology, and biodegradable polymers have been evaluated for use in surgery, tissue engineering and targeted drug delivery. We examined the tissue reactions attributable to 3 biodegradable polymers in the rat eye. METHODS:Inion GTR™ membrane [a blend of 85:15 poly(L-lactide-co...

journal_title：Ophthalmic research

authors： Rönkkö S,Kaarniranta K,Kalesnykas G,Uusitalo H

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To study the ability to appreciate qualitative features that indicate disease activity in patients with neovascular age-related macular degeneration (AMD) and to analyze the differences in automated retinal thickness measurement, using 1 time domain optical coherence tomography (TD-OCT) and 2 different spectral...

journal_title：Ophthalmic research

authors： Querques G,Forte R,Berboucha E,Martinelli D,Coscas G,Soubrane G,Souied EH

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:To evaluate the role of initial visual acuity (VA) as a potential prognostic factor for final VA in patients with branch retinal vein occlusion (BRVO). METHODS:A retrospective data analysis involving 163 patients with macular edema secondary to BRVO treated according to the recommendations of the Branch Vein O...

journal_title：Ophthalmic research

authors： Rehak J,Dusek L,Chrapek O,Fric E,Rehak M

更新日期：2011-01-01 00:00:00

abstract：:To determine the conditions under which anesthetized pigs can be used in acute noninvasive investigations of ocular hydro- and hemodynamics, the intraocular pressure (IOP) of adult pigs was recorded under the following conditions: (1) after intravenous injection of propofol plus ketamine; (2) during inhalation of isof...

journal_title：Ophthalmic research

authors： Buehner E,Pietsch UC,Bringmann A,Foja C,Wiedemann P,Uhlmann S

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:The traditional medium for storing corneas in European Eye Banks is Gibco's MEM (Eagle's) with Earle's salts and Hepes containing 2% fetal calf serum, glutamine and antimycotics. Although serum-free MegaCell MEM has been reported to be more suitable for this purpose, it contains components of animal origin that...

journal_title：Ophthalmic research

authors： Smith VA,Johnson T

更新日期：2010-01-01 00:00:00

abstract：AIMS:Experimental retinal research has gained great importance due to the ophthalmic pharmacotherapy era. An increasing number of drugs are constantly released into the market for the treatment of retinal diseases. In this review, animal species, animal models and toxicity assays in retinal research are discussed. MET...

journal_title：Ophthalmic research

authors： Penha FM,Rodrigues EB,Maia M,Dib E,Fiod Costa E,Furlani BA,Nunes Moraes Filho M,Dreyfuss JL,Bottós J,Farah ME

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:The lens is the ocular structure most susceptible to oxidative damage. Antioxidants, micronutrients and phytochemicals have been extensively studied for their possible effects to prevent or delay the progression of various eye diseases. OBJECTIVES:A brief overview of the updated literature on the role of an...

journal_title：Ophthalmic research

authors： Agte V,Tarwadi K

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Weak oxidants produced by activated human leukocytes are proven antimicrobial substances. We tested whether N-chlorotaurine (NCT, taurine chloramine), the chlorinated metabolite of the amino acid taurine, in addition to direct virucidal effects on viral suspensions, has the capability to prevent cell-to-cell ...

journal_title：Ophthalmic research

authors： Huemer HP,Nagl M,Irschick EU

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:This study was performed to examine the location, width, and insertional shape of rectus extraocular muscles (EOMs), and to elucidate the symmetry of the insertional anatomy of rectus EOMs in the left and right eyes. METHODS:EOMs were dissected from their origin to the insertion point in 100 intact orbits of 5...

journal_title：Ophthalmic research

authors： Cho HK,Shin SY

更新日期：2010-01-01 00:00:00